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- O.C.
- Omar Credle, MC (US)
- OC
- Oscar Edriguez, MC (US)
- Ol' Dirty Bastard
- Russell Jones
- One Eye Q
- Ayo Dele Ajaji (One Eye-Q=Young Wizdom), Swedish MC.
- Onyx
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- Opio
- Opio Lindsey (from hieroglifics)
- Organized Konfusion
(group)
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- Outkast
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- Overlord X
- Benjamin Balogun, UK MC.
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