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- Saafir
- Reggie Gibson
- Sadat X
- Derrick Murphy, MC (US)
- Salt
- Cheryl James, MC (US)
- Salt-N-Pepa
(group)
-
- Sam Sever
- Sam Citrin, US producer.
- Sam Sneed
- Sam Anderson, MC, producer (US)
- Sammy B
- Samuel Burwell (Jungle Brothers), US DJ.
- Sassy C
- Michelle Franklin (JJ Fad), US MC.
- Sauce Money
- Todd Gaither, MC (US)
- Saukrates
- Amani Wailoo
- Scarface
- Brad Jordan, MC (US)
- Schoolly D
- Jesse B. Weaver Jr., MC (US)
Philidelphia based Schoolly D. was the first gangsta rapper with the song "P.S.K. (what does it mean?)".
- Scorpio
- Eddie Morris (Younger Generation/Furious Five), US MC.
- Scott La Rock
- Scott Sterling (Boogie Down Productions), US DJ.
- Screwball
(group)
-
- Sean C
- Sean Matthews, US DJ.
- See Que
- Cherno Jah, Swedish MC.
- Sen Dog
- Senen Reyes (Cypress Hill), US MC.
Sen Dog was born in Havana, Cuba.
- Sequence
(group)
-
- Seven Eleven
(group)
-
- Shabba Ranks
- Rexton Rawlston Fernando Gordon
- Shabba Ranks
- Clifton Dillon
- Shah
- Ali Shaheed Muhammad (A Tribe Called Quest)
- Shallah Raekwon
- See Raekwon the Chef.
- Sham
- K. Gill (Sham & The Professor)
- Shawn J-Period
- S. Jones
- She
- Sheila Spencer, US MC.
- Sheek
- Sean Jacobs
- Shinehead
- E.C. Aiken Jr.
- Shock G/Shockalock
- Gregory E. Jacobs (Digital Underground), US MC.
- Shockin' Shaun
- Shaun Harrison (Skinny boys), US MC.
- Shogun Assason
-
- Shorty
- Jerome Washington (Lench Mob), US MC.
- Shorty
- Zach Flowers (Explicit Lyrics)
- Shorty No Mas
- Terresa Thompson
- Showbiz
- Rodney Lemay
- Showbiz & AG
(group)
-
- Shuga
- Chris Liggo.
- Shy D
- Peter Jones, US MC.
- Shyheim the Rugged Child
- Shyheim Franklin, MC (US)
- Shyne
- Jamal Barrows
- Side FX
(group)
-
- Silk
- Vickie Jordan (Silk Tymes Leather)
- Silkk the Shocker
- Zyshonne Miller
- Silver Bullet
-
- Simple E
- Erica Williams, US MC.
- Sinister
- Joe Wright, US DJ.
- Sir Downset
- Daniel Leonard
- Sir Jinx
- Tony Wheatob (C.I.A.), US MC and producer.
- Sir Mix A Lot
- Anthony Ray, US MC.
- Sir Raphael
- John Allen.
- Sir Scratch
- Shawn McKenzie (Main Source), US DJ.
- Sisqo
- Mark Andrews
- Sister Souljah
- Lisa Williamson, US MC.
- Skoob
- Willie Hines (Das EFX), US MC.
- Sleek
- Kerwin Young, US producer.
- Sleepy
- Patrik Elofsson, Swedish DJ.
- Sleepy John
- Johnny Rivers, US producer.
- Slice
- Michael Brown (Kool Rock Jay), US DJ.
- Slick Rick
- Ricky Walters, MC (UK / US)
- Slim Kid 3
- Trevant Hardson (Pharcyde), US MC.
- Slugster
- Ryan Madayag
- Smif N Wessun
-
- Smooth
- Juanita Stokes
- Smooth
- Ira McLaughlin, US MC.
- Smooth Bee
- Darryl Barnes, MC (US)
- Smoothe Da Hustler
- D. Smith
- Smoove
- Kenny Kornegay.
- Snoman
- LeBaron Frost
- Snoop Doggy Dogg
- Cordazer Calvin Broadus,, MC (US)
- Snow
- Darrin O'Brien
- Snupe
- Duane Lee (Hieroglyphics), US MC.
- Son Doobie
- Jason Vasquez (Funkdoobiest), US MC.
- Son Of Bazerk
- Timothy Allen
- Soul Man
- Kevin Jones, US MC.
- Soulja Slim
- James Smith
- Souls of Mischief
(group)
-
- South Central Cartel
(group)
-
- Special Ed
- Edward Archer, US MC.
- Speech
- Todd Thomas (Arrested Development), US MC.
- Speed Knock
- Fredrik Lundbom (Sherlock), Swedish MC.
- Spice 1
- Robert Green Jr.
- Spinderella
- Latoya Silk (first Salt-N-Pepa, later solo), US DJ. Was their first DJ and featured on the first album.
- Spinderella
- Deedee Roper (Salt-N-Pepa), US DJ. From their second album on.
- Spirtit Philled
- Philip Hernandez (K II S), US MC.
- Spliff Star
- W. Lewis
- Spoonie Gee
- Gabriel Jackson, US MC.
- Spunk Bigga
- Anthony Blagmon.
- Spyder D
- Duane Hughes, US MC.
- Steady B.
- Warren McGlone (C.E.B.), US MC.
- Steinski
- Steve Stein, US Producer.
- Steve
- Steve Leonard (Knuckleheadz), US MC.
- Sticky Fingaz
- Kirk Jones (Onyx), US MC.
- Stranger
- David Seisay, US/Swedish rapper.
- Stretch
- Randy Walker (Live Squad), US MC & producer.
- Studio Ton
- Ton Whiteman (Sick Wid It's producer)
- Styles
- David Styles
- Suga Slimm
- Ronald Williams
- Suga T
- T. Stevens
Sister of E-40 and D-Shot, cousin of B-Legit and Mac Mall.
- Sugarhill Gang
(group)
-
- Super Cat
- William Maragh
- Super Jay
- James Harrison (Skunny Boys), US MC.
- Super Lover C
- Calente Fredericks
- Super Rhymes
- Jimmy Spicer
- Suzie Q
- Susan Banfield (Cookie Crew), UK MC.
- Sweat
- Lamond Cogdell, US MC.
- Sweed LD
- Djuana Johnican (Oaktown 357), US MC.
- Sweet Id
- Djuana Johnican (Oaktown's 357's), US MC.
- Sweet Tee
- Tanya Winley (Daughter of record label owner Paul), US MC.
- Sweets
- K. Lyda
- Swing
- Richard Anthony Silva, US/Swedish MC.
- Swizz Beats
- Kaseem Dean
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